측두하악관절 장애 환자에서 관절원판후조직의 에스트로겐 수용체(ER)의 단백 발현

Kim Jong-Yun; Lim Jae-Hyung; Park Kwang-Ho; Kim Hyung-Gon; Huh Jong-Ki

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측두하악관절 장애 환자에서 관절원판후조직의 에스트로겐 수용체(ER)의 단백 발현
EXPRESSION OF ESTROGEN RECEPTORS IN RETRODISCAL TISSUE OF THE TEMPOROMANDIBULAR JOINT DISORDER PATIENTS

대한구강악안면외과학회지 2009년 35권 6호 p.403 ~ 410

김종연, 임재형, 박광호, 김형곤, 허종기,

소속 상세정보

김종연 ( Kim Jong-Yun ) - 연세대학교 강남세브란스병원 구강악안면외과
임재형 ( Lim Jae-Hyung ) - 연세대학교 강남세브란스병원 구강악안면외과
박광호 ( Park Kwang-Ho ) - 연세대학교 치과대학 구강악안면외과학교실
김형곤 ( Kim Hyung-Gon ) - 연세대학교 치과대학 구강악안면외과학교실
허종기 ( Huh Jong-Ki ) - 연세대학교 치과대학 구강악안면외과학교실

KMID : 0355620090350060403

Abstract

Those composing temporomandibular joint (TMJ) complex such as the temporal bone, the disc and the mandibular condyle perform their own functions with organic relation. The retrodiscal tissue is the main area of pain induction and contributes to compositional change of synovial fluid. If displacement of the disc lasts long time, not only adaptive changes, but also destructive or degenerative changes may happen. It was reported that these changes and symptoms appear mostly to female rather than male and especially, in the case of patients suffering from TMJ disorder, a large quantity of female sex hormone is found in the joint synovium. And that may play a role in bone resorption and inflammation. Also, the frequency and the intensity of pain perception for female is reported to be much more than for male. In this study, we investigated the expression extents of estrogen receptors (ER) and progesteron receptors (PR) in retrodiscal tissue with immunohistochemistry among the patients received TMJ surgery and compared with MRI findings and surgical findings. We report the relations between the expression of ER in retrodiscal tissue and the pathological change in TMJ, such as inflammation, internal derangement and osteoarthritis.